The global high-performance liquid chromatography market size is expected to reach USD 7.03 billion by 2030, registering a CAGR of 6.0% from 2025 to 2030, according to a new report by Grand View Research, Inc. Rapid growth in pharmaceutical production, stringent regulatory norms for drug purity, and increasing adoption of high-performance liquid chromatography (HPLC) techniques for diagnostics and research purposes are driving the market.

HPLC is commonly used for the assessment of drug purity on an industrial scale. It also enables characterization of molecules being explored as potential new drug candidates. Demand for the technique is anticipated to grow due to its increasing applications in ensuring consistency and determination of dosage of active pharmaceutical ingredients. Furthermore, the technique holds significance in quality control testing for assuring the fulfillment of critical quality attributes in the pharmaceutical industry.

The technique is augmenting clinical diagnostic services due to the availability of improved stationary phase alternatives and multiple channel HPLC instruments that can aid in sequential analysis of patient samples. Such attributes are desirable for low- or moderate-throughput laboratories and enable faster turnaround times. Similarly, recent developments in column technologies are increasing the efficiency of HPLC operations and are likely to fuel the market growth. For instance, the advent of2-µm superficially porous silica particles has led to improved HPLC operations at comparatively lower back-pressure and with the use of shorter columns.

Furthermore, companies involved in the market are launching new HPLC-based analyzers and systems for capitalizing on the expanding scope of applications for the technique. For instance, in June 2021, Trivitron Healthcare launched two new HPLC analyzers, NANO H5 NANO H110, intended for the detection of HbA1c and Hb variants in less than three minutes.

In addition, the COVID-19 pandemic has accelerated the adoption of HPLC systems for the development of new therapeutics, vaccines, and reliable diagnostic methods for the disease. Furthermore, epidemiological applications of the technique for the characterization of viral proteins are expected to gain traction due to the emerging mutations of the SARS-CoV-2 virus. These factors are anticipated to positively affect the market growth.

High-performance Liquid Chromatography Market Segment Highlights

• By product, the instruments segment held the largest revenue share of 48.2% in 2024 due to the increasing dominance of integrated HPLC systems and the availability of advanced detectors.
• Based on application, Clinical research applications accounted for the largest revenue share of 40.7% in 2024. This growth can be linked to the increasing scope of clinical trial activities, a rise in biopharmaceutical research and development, and a growing demand for high-throughput analytical techniques.
• By end-user, pharmaceutical and biotechnology companies dominated the market and accounted for 41.9% share in 2024. Within these companies, HPLC methods are employed for various applications, including quality control, drug purity determination, characterization of drug candidates, and evaluation of the stability of active ingredients in pharmaceuticals.
• The North America market dominated the overall global market and accounted for the 31.68% of revenue share in 2024.
• The Asia Pacific market is experiencing the fastest growth, driven by significant innovations in healthcare infrastructure and technology.

Browse through Grand View Research's Clinical Diagnostics Industry Research Reports.

• The global spectrometry market size was estimated at USD 19.71 billion in 2024 and is expected to grow at a CAGR of 7.7% from 2025 to 2030. 
• The global helicobacter pylori diagnostics market sizewas estimated at USD 698.44 million in 2024 and is expected to grow at a CAGR of 5.87% from 2025 to 2030. 

Segments Covered in the Report

This report forecasts revenue growth at country levels and provides an analysis on the latest industry trends and opportunities in each of the sub-segments from 2018 to 2030. For this study, Grand View Research has segmented the high-performance liquid chromatography market report based on product, application, end-use and region.

High-performance Liquid Chromatography Product Outlook (Revenue, USD Billion, 2018 - 2030)

• Instruments
  • HPLC Systems
  • Pumps
  • Detectors
  • Others
• Consumables Accessories
  • Columns
    • Reverse-phase HPLC Columns
    • Normal-phase HPLC Columns
    • Ion Exchange HPLC Columns
    • Size Exclusion HPLC Columns
    • Other HPLC Columns
  • Filters
  • Vials
  • Tubes
  • Others
• Software

High-performance Liquid Chromatography Application Outlook (Revenue, USD Billion, 2018 - 2030)

• Clinical Research Applications
• Diagnostic Applications
• Forensic Applications
• Other Applications

High-performance Liquid Chromatography End-use Outlook (Revenue, USD Billion, 2018 - 2030)

• Pharmaceutical Biotechnology Companies
• Academic Research Institutions
• Others

High-performance Liquid Chromatography Regional Outlook (Revenue, USD Billion, 2018 - 2030)

• North America
  • US
  • Canada
  • Mexico
• Europe
  • UK
  • Germany
  • France
  • Italy
  • Spain
  • Norway
  • Denmark
  • Sweden
• Asia Pacific
  • Japan
  • China
  • India
  • Australia
  • South Korea
  • Thailand
• Latin America
  • Brazil
  • Argentina
• Middle East Africa
  • South Africa
  • Saudi Arabia
  • UAE
  • Kuwait

Order a free sample PDF of the High-performance Liquid Chromatography Market Intelligence Study, published by Grand View Research.